NGS in CML - New Standard Diagnostic Procedure?

Please see the following page from iCMLf for full details:

https://www.cml-foundation.org/science-education-mobile/virtual-education-mobile/1336-vep-44.html

Associate Professor Susan Branford, Centre for Cancer Biology Adelaide, Australia

• CML is a genetically uniform disease: BCR-ABL1
• Catalogue of somatic mutations in cancer: COSMIC
• Sanger sequencing is impractical for broad discovery
• Association of mutated cancer genes and transformation
• New therapies for BC based on mutation profile
• Other genes not listed in the cancer gene census?
• Multiple genomic events may impact outcome