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Glossary beginning with T
T
- Tasigna
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The commercial name for nilotinib.
- Thrombocytopenia
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The condition of having abnormally low numbers of platelets.
- Thrombocytosis
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The condition of having abnormally high numbers of platelets.
- TKI
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Tyrosine Kinase Inhibitor (TKI), a molecular targeted therapy designed to block specific proteins that cause leukaemic cells to divide. Imatinib was the first generation in this class of oral therapy; dasatinib, nilotinib, bosutinib and ponatinib are second generation TKIs now used as 1st, 2nd, 3rd and 4th line therapy.
- Translocation
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An event that occurs when part of one chromosome breaks off and attaches to a different chromosome. In 1973, Janet D. Rowley at the University of Chicago described the mechanism by which the Philadelphia chromosome arises as a reciprocal translocation between chromosomes 9 and 22.
- Tyrosine kinases
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proteins that play a key role in cell signalling processes.