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BCR ABL IS on the rise

Since my detection in last November, I am on Imatiniv. Due to serious side effects doc had to reduce my dose from 400 to 300. I am on it till today. Last month my BCR ABL IS has increased from 1.28(May18) to 1.78. Is there anything I should be worry about? Mutation Study report is NEGATIVE. Before giving me MUTATION ANALYSIS test he was talking about increasing my dose.

I fear my days of suffering.

Change drugs.
(Same thing happened to me with imatinib. It didn't work, so I was switched to sprycel which did work (and on a very low dose as well).