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Tasigna/Nilotinib to Sprycel/Dasatinib switch ?

Hello,

I was diagnosed with CML in May 2022 and on tasigna/nilotinib ever since. Lately, my PCR results have been stagnating with a slight upwards trend (0.22 in July 23, 0.25 in November 23 and 0.31 in April 24), which concerns me somewhat.

I did a resistance test and have none.

My haemotologist offers me to switch to sprycel/dasatinib.

Has anybody else switched from nilotinib tò dasatinib? What was your experience?

Any input appreciated 🙂

I switched from Spyrcel to Nilotinib as the Spyrcel was causing pleural infusion. In between I was taking Bosutinib for a year but I too had an upward trend.
A month now on 400 morning and 400 evening. It’s really hard on my body. Headaches, bone pain, nausea.

I was on Sprycel for two years and the problem was pleural effusion, to me was unnoticed until I did a abdominal Xray for something totally different, and noticed the fluid in the right lung (1.5 liters ) my doc switched to tasigna 150 mg twice a day, but last month I had Pancreatitis ( a side effect of the Drug) and now the PCR AaBL is scaling up, my doc scheduled a resistance test, hopefully is okay, tired of changing drugs!
But, to answer your question, every of these TKI drug have a side effect, and at least one of them is enough to stop taking the drug for other health reasons, for me was Scary Low Platelet at first, then Pleural effusion, and now pancreatitis , luckily there ar many TKI drugs and hopefully your body will react better to one vs the other.
Good luck,
G