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Concerning BCR-ABL1 upward

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Hi All,

I am new to this forum, and I was diagnosed with CML last year. I have the below queries and would really appreciate if someone could share their feedback.

Clinical History:
Feb 2024 - Diagnosed with CML
Mar 2024 - Started Imatinib 400mg daily to date

BCR-ABL results:
Feb 2024 - 19.72% (during diagnosis)
May 204 - 0.124%
Jul 2024 - 0.001% (achieved DMR)
Jan 2025 - 0.017%

Demographics:
38 years old, Female, married and have two kids under 10, living in south east Asia

My Queries:
I am really worried for the increase in the latest BCR ABL result. Though I read in other threads this is normal, but this a more than a 1log increase. I will be meeting my oncologist in few days, but I wanted if anyone else experience a similar increase after achieving DMR.

I wouldn't worry, but would suggest you get another test in 3 months rather than 6. As an 18 year veteran of these test results, I'd say that your July 2024 result which showed a 2 log drop in 2 months looks a bit suspect. 0.017% is still a great result. Try to get a retest in March/April and see what it says.

Thank you for your feedback, I feel relieved. My next appointment with oncologist is due tomorrow, will see what his thought on this