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BCR ABL - 0.014 after 3 years

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Hi all

After 3 years of Undetection, my result suddenly showing 0.014

I had reduced the dose to 200mg bid. I started back to 400mg bid now

Is this temperory? Or resistance/mutation. Kindly help with understanding.

I had a similar experience with Nilotinib. I went almost two years undetected, at the mark of the first year I dropped my dose by 50mg / day. Right at the 2 year mark it went up. Which tells me my sweet spot is somewhere between 400 and 450 mg / day. And it also convinced me that I will never achieve TFR. At least not now.

JP

0.014% is within the range of repeatability of the test. I wonder if the next test might revert to undetectable - think it might have been worth waiting until your next test to see if an upward trend continues before changing. Hope it comes back down soon.