I have listed a few Abstracts I found interesting from this years 56th ASH Meeting currently taking place in San Francisco CA. This can also be found on the Conferences Page alongside summaries of other meetings and conferences. Sandy
You are here
ASH 2014- CML Abstracts of interest
Thanks for drawing our attention to this, Sandy.
I was interested in the report of the INTERIM trial, where a group of people aged over 65 and on imatinib, took alternate months off the drug. Many people seemed to do OK, and those who did less well were able to get back to where they were before. Do you know of anyone in the UK who was on this trial, or was it only in the USA?
If it would be possible, I'd love to give it a try - it would be good to know which of my aches and pains are attributable to imatinib, and which to increasing age!
Hi Olivia,
Unfortunately this trial has now been completed. Looking at the trial information on the following link, it seems that is was only conducted in Italy.
I am not sure if there is going to be another or if it is to be repeated elsewhere, but it may be a good idea for you to talk with your doctor about the possibility of you trying this kind of protocol outside of a trial setting but with increased monitoring of course. If your PCR is low and stable it might be possible for you to try this under the close care of your doctor?. If I hear of any similar studies I will of course let you know.
http://clinicaltrials.gov/ct2/show/NCT00858806?term=NCT+00858806&rank=1
Sandy
I have added to the list of abstracts- see pdf in post above.
Scroll down for link to an interesting paper on ABL001 and its phase 1 clinical trial for CML and AML- currently open in US, Australia, Japan, Korea, Singapore, France, Italy, Spain, Germany and Netherlands.
You can also find information on this trial on our clinical trials page which I posted earlier this year.
It will be one to watch.
Great news, sandy!!! future for cmlers will be brilliant!! can't wait for the next 5-10 years. My doctors is attending to ash and i have an appointment with her next friday. i'll ask about the cml presentations.
"512 Cooperative Targeting of Bcl - 2 Family Proteins by ABT - 199 (GDC - 0199) and Tyrosine Kinase Inhibitors to Eradicate Blast Crisis CML
and CML Stem/Progenitor Cells"
https://ash.confex.com/ash/2014/webprogram/Paper72972.html
Any word on when trials for this will start?
If i read it correctly, it has potential, for treating Blast phase CML, and maybe even eradicating the disease for all of us?
There has been some interest in this via posts on this forum earlier this year- and as my mum has CLL I have been watching the results of the c/trials for CLL and it seems to be having some success in refractory CLL. There is an article in D/Mail about a man who was suffering from aggressive stage CLL who has responded to ABT 199 via a trial at Christies Hospital Manchester. (CLL is not really a leukaemia but is considered to be a kind of lymphoma) See manufacturers paper presented at ASCO in May this year.
http://www.marketwatch.com/story/abbvie-presents-new-results-from-studie...
However, it seems to be synergistic with TKI- imatinib- in CML....
see this paper from April this year which says...
'while single agent ABT-199 has modest activity against CML progenitors, when combined with imatinib, ABT-199 significantly enhances imatinib activity against CML progenitors at concentrations predicted to avoid hematologic toxicities'
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&pa...
So yes you are right- there is great potential for CML in Blast phase and maybe even holds promise for all of us!
Sandy