Hi Karrine,
The reason I reply to you is that I was considering niacin or Vitamin B3 as my uric acid is low and this would push it up nearer to normal.Niacin it seems occurs naturally in peanuts and tuna and I believe is very evident in Marmite or Vegemite.Apparently an overdose of niacin say taking 2000mg per day might causes ulcers of the stomach,and lead to liver damage.It might lead to elevation of uric acid in the blood and lead to gout and it might lead to higher blood sugar.It would apparently interact with caffeine.I see that you intend to take 1000 mg daily.I think that I would be cautious about taking any supplement to excess when taking a tki-many of the tkis hammer the liver so taking a high dose of niacin might prove to be unwise.
If you wish to reduce your cholesterol then one might first seek advice from a doctor to see what other medicine might be offered and to seek advice regarding the fairly high dose niacin that you propose and you might need to monitor your uric acid level.
I am not sure if I need to take action to increase my low uric acid level-my doctor says it is not an issue and is not needed.
I trust then helps a little
Best wishes
John