Hello,
My partner has been on dasatinib for two weeks now and we noticed a rash that appeared on Friday. For the first week she was also taking allopurinol and stopped on Wednesday.
The first blood results came out good, the wbc dropped from 50,000 to 16 in just a week, the platelets are still elevated to 530 , but are decreasing slowly.
The rash appeared on Friday morning (she takes sprycel at 9am) so we looked for solutions and found out that cetirizine can be effective so she took 10mg at 1pm alongside with Eurax cream. On the next morning, majority of the rash has disappeared and seems that the 10mg of cetirizine worked well. So she continued taking Dasatinib as usual, the rash wasn’t developing , quite the opposite all of it disappeared on Saturday evening. We emailed our nurse telling her about the rash and she told us to stop taking dasatinib which we did from today until our next visit which is tomorrow to discuss further.
As of now, the rash has gone and we are debating what caused it, we are thinking that allopurinol could be the cause or something else triggered the rash, as she continued to take dasatinib and it still went away. The rash was normal to the touch , not warm, kind of looked like stinging from nettles but more flat and was only itchy, without any fluid inside.
She also had a small nose bleed today when blowing her nose in the morning which stopped in less than 2 mins.
We are worried that our consultant might want to switch her from dasatinib to nilotinib as she had minor side effects on Sprycel, even though it might be too early to tell as shes been on it for only two weeks. But overall the first 2weeks were fine and she was able to work from home as normal.
She was also referred to dermatology unit and they suggested a drug allergy test.
maybe its worth adding the supplementation she also takes:
vitamin d3 5000ui with k2 as mk7
Curcumin c3 complex 6g daily - but cause of the nose bleed will reduce the dose or perhaps stop for awhile
Vitamin c 500mg
Zinc 25mg
Magnesium 250mg
Selenium 250mg or 3 brazil nuts
Vit b12 complex
Is stopping dasatinib the right choice for some time and restarting soon?
perhaps changing to nilotinib is the better solution ?
We are hoping to restart Sprycel but perhaps on a lower dose to prevent the rashes from appearing, if this was the cause in the first place?
Anyone developed a rash whilst on Dasatinib? I believe its a common side effect of most TKI’s and how your consultants reacted ?
looking forward for your views :)