Hello,
How many out there have this mutation?
For those who have or had it, I have several questions.
1) How have you and your team addressed this in general?
2) Did you experience TKI resistance?
3) Have you and your team looked into ALOX5 inhibitors?
For #2 and #3, I've come across some interesting studies. One of the more interesting studies is:
CML With Mutant ASXL1 Showed Decreased Sensitivity to TKI Treatment via Upregulation of the ALOX5-BLTR Signaling Pathway
PMID: 39905783 PMCID: PMC11967257 DOI: 10.1111/cas.70007
Thank you and look forward to your input.