Trying to conceive

Hi,

It’s safe to father a child on dasatinib without interruption of therapy. This has been established for quite a few years now, and will be explicit in the ELN 2025 CML guidelines which were announced at the EHA conference just the other day, but are not yet available to view. They will be soon.

But for something that is published, look to the BSH guidelines that specifically say: “The risks of adverse consequences of pregnancy for partners of men taking TKI are similar to the risks in the unaffected population.”

https://onlinelibrary.wiley.com/doi/10.1111/bjh.16971

Also look at the NCCN guidelines that say “TKI therapy appears to affect some male hormones at least transiently, but it does not appear to have a deleterious effect on male fertility. Furthermore, the miscarriage or fetal abnormality rate is not elevated in female partners of males on TKI therapy.”

https://jnccn.org/view/journals/jnccn/22/1/article-p43.xml

So all in all the science says it is safe to father a child on dasatinib, with many years of observation behind it.

On a personal note I fathered my children while taking dasatinib.

David.