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No MMR after taking Nilotinib for three years.

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After taking Nilotinib for three years, the PCR test bouces back to 0.53%. Before it was 0.38%, and once 0.13%. What should I do? Third generation medicine is toto expensive. Doctor recommends using Dasatinib. What should I do?

Have you been on any other TKIs? You may benefit from a switch. Have you tried Imatinib? Looks like your numbers are somewhat steady but I personally prefer to remain lower than MMR or MR3.

Joe

Yes, I tried Flumatinib at my first diagonosis, but it made my platelets drop to single number. Then one doctor recommed switching to Nilotinib. So I have been taking it for three years by now. But a few months ago, I ran out of medicine, and didn't take Nilotinib for over 20 days, I don't know how significant that had on my results. I also smoke a litttle, eat spicey food. I did't follow the instructions that no food 2 hours before and 1 hours after taking medicine.