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Should I avoid anti-oxidants while taking Scemblix?

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Hi, I've recently switched from Imatinib to Scemblix (80 mg day) and am wondering if Scemblix works through ROS (reactive oxygen species) activity the way Imatinib does. When I began taking Imatinib more than 4 years go, I saw some research indicating potential reduced efficacy with Imatinib if you take anti-oxidant supplements or eat too many anti-oxidant-rich foods, but I can't find any research on ROS and Scemblix online. I asked my dr. but he was not certain, so I called the manufacturer (Novartis) but they only give that info peer to peer (to another medical professional), so I circled back to my drs. office to ask someone to call Novartis, but so far I have not heard back.

Has anyone seen any info about this? I'd love to add anti-oxidants back into my diet/list of supplements, but hesitate due to not having clarity on this topic. Thanks in advance, Ann

please excuse my 1-finger typing.
i take my supplements while on scemblix. I took supplements while on imatinib and dasatinib. I believe some docs and online advisors will agree and some will disagree as to whether the supplements help.
I take the supplements to prevent side effects from the tki's. i've seen literature that states some of my supplements help with the bcr/abl numbers. I tend to agree,based on my PCR tests on low dose tki's.
there is a "Drug Interaction Checker" on drugs.com to help with your decision.

Thank you! I completely agree that supplements help, both in reducing side effects and with the bcr/abl numbers. I take milk thistle, selenium, zinc, vitamin K, Vitamin E, and a multi-B vitamin. I appreciate your reply- this morning I heard back from my doctor's office and I don't need to avoid anti-oxidants on Scemblix, which is a big relief. I will take a look at the drug interaction checker on drugs.com.

the liver enzyme cyp3a4 breaks down various tki's.
I look up to see if my supplements{anti-oxidants/vitamins/herbs} slow or speed up the tki breakdown. and decide what to do,and, of course, the oncologist knows of my supplements.
I take about 50 different supplements each day for energy, calming purposes, preventive purposes {ex.,migraines,family history diabetes}. I took most of the supplements before the CML diagnosis. I am an old man,fit for my age, on no script besides the tki's i've taken in the past 3 years.. so I believe my supplements help.
no reply is necessary. I would answer your questions.

the liver enzyme cyp3a4 breaks down various tki's.
I look up to see if my supplements{anti-oxidants/vitamins/herbs} slow or speed up the tki breakdown. and decide what to do,and, of course, the oncologist knows of my supplements.
I take about 50 different supplements each day for energy, calming purposes, preventive purposes {ex.,migraines,family history diabetes}. I took most of the supplements before the CML diagnosis. I am an old man,fit for my age, on no script besides the tki's i've taken in the past 3 years.. so I believe my supplements help.
no reply is necessary. I would answer your questions.

Thank you for this explanation. I am 68 and other than the CML (diagnosed in 2021) I had no health issues (except chemical sensitivity to certain substances, such as paint/varnishes, and new carpet/padding).

Other than Scemblix I only take Levothyroxine in the smallest dose due to the impact of TKI's on the thyroid. I won't ask you to list all of those supplements but I wholeheartedly agree that they are both supportive and preventative, and a very good idea to include in one's daily regimen. Blessings to you on your healing journey, and many thanks again.