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Food & Drug Interaction Chart

Hi All,

I recently came across a food and drug interaction chart that has been compiled by the Candian CML Society. It looks like an easy to read fairly comprehensive list, but there are things on there that we have never been told to avoid or to check before taking. Could those of you with more knowledge in this area take a look through it and perhaps provide some feedback on how accurate the list is please.  For example, it seems to suggest that drinking a lot of peppermint tea, or eating a lot of garlic are a no-no.

http://www.cmlsociety.org/files/documents/CMLDrugInteraction2%20August%202010.pdf

Thank you in advance

Hi Bhiru

I would check with Prof Apperley or David Marin.  so far as I know the interactions differ from drug to drug and this list is all encompassing. Eg I take omeprazole (low dose) to deal with reflux that's much worse on glivec.  That's fine with glivec but not on dasatinib (not sure about nilotinib).  Also, the chart does say that for some of these esp the food ones, "more research is needed" so again I would check. It may be with things like peppermint tea and garlic you need to consume an awful lot before any effect and/or close to your dose - dont' know but I'd ask and relating to the particular TKI you're on. 

It's my understanding too that many patients in the US are advised not to consume alcohol while on TKIs.  I was told expressly at diagnosis that you can.  I am more careful than I was for sure but I still enjoy wine. Would be different if there was evidence of liver enzyme changes - some do get that (and it is monitored).

Hope Jed's doing well.  He did such a great job with the media over the NICE ACD. 

Richard

Was just about to post this link, but would have mirrored some of the comments that Richard has made!


I do think it's worth keeping an eye on this list as my GP prescribed an antibiotic that's on the list and when I asked him to check with the hospital, they confirmed that it was best avoided. Also, I was on high doses of Omeprazole, night and morning, but I do have a very well informed Pharmacist who told me that I would be OK to have the high dose, but to space it twelve hours from taking Dasatnib. So, I think that like most things, you steer a course that's a compromise. I have both garlic and Peppermint tea, but in moderation.

What's interesting is that, because a GP is unable to prescribe TKI's, they are also unable to access interaction information. on the computer! I try to remember to take the leaflet along with me if I need a prescription and I would advise others to do the same.


I too enjoy my evening wine and, as Richard says, any problems with the liver show up when the regular tests are done.

 

ATB

Vic